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Chronic central (intracerebroventricular) or peripheral (subcutaneous) infusion of GIP analogue in mice increased cFos neuronal activity in hypothalamic feeding center, resulting in reduced food intake and body weight

(Off-label use means a medication is prescribed to treat something other than what it's FDA-approved for.) Only Wegovy is FDA-approved for chronic weight management

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Some experts note that better mental health often follows improvements in physical health, making it difficult to disentangle whether GLP-1 drugs have unique neurobiological effects or whether benefits arise from downstream consequences like weight loss and stabilized blood sugar

These agents activate the cAMP-PKA signaling cascade in pancreatic -cells 6 , resulting in glucose-dependent insulin secretion, suppression of pancreatic -cell glucagon release, and modulation of gastrointestinal motility through delayed gastric emptying 7