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Ozempic, Wegovy, Mounjaro , and Zepbound all play significant roles in the sphere of weight management, though they differ in their mechanisms and areas of impact

Several important safety considerations from UK SmPCs include: Pancreatitis risk : Seek immediate medical attention for severe, persistent abdominal pain Gallbladder disease : Including cholelithiasis and cholecystitis Diabetic retinopathy complications : Particularly with semaglutide in those with pre-existing retinopathy Dehydration and acute kidney injury : Possible with severe gastrointestinal side effects Hypoglycaemia : Increased risk when used with insulin or sulfonylureas (dose adjustment of these medications may be needed) Pregnancy/breastfeeding : Weight management GLP-1 agonists (Wegovy, Saxenda) are contraindicated in pregnancy and should be avoided during breastfeeding [5] [2] Regarding mental health specifically, regulatory agencies have scrutinised GLP-1 medications for potential psychiatric adverse effects

Novo Nordisk's Ozempic and Eli Lilly's Mounjaro are not approved for weight management

In recent years, GLP-1 role in neuronal pathways has expanded its therapeutic potential

On March 11, 2026, Eli Lilly and Company announced plans to invest approximately $3 billion over the next decade to expand its supply chain capacity in China

Baseline characteristics