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CNNs Meg Tirrell and Tami Luhby contributed to this report.

The combination yields greater weight loss than either agent alone, with mean reductions in body weight of approximately 20.4% over 68 weeks in non-diabetic adults and 13.7% in those with type 2 diabetesfar exceeding placebo and monotherapy arms

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Given this confirmation of positive phase 2 results, were raising our probability of approval to 60%, which raises our sales estimate to $8 billion by 2033
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