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But the therapeutic effect is not just about peak levels
According to FDA prescribing data , nausea affects up to 20% of patients on semaglutide, while vomiting and diarrhoea affect roughly 8% to 12%

Specification of Target Trials Study Overview We compared semaglutide or tirzepatide with other antidiabetic medications for the associated risk of optic nerve and visual pathway disorders in patients with type 2 diabetes who had no prior diagnosis of any eye disorder (determined by the absence of International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ ICD-10 ] codes H00-H59, Diseases of the eye and adnexa, documented in EHRs) using a target trial emulation framework

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Harris will review history + labs)
