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Mayoral LP, Andrade GM, Mayoral EP, et al
GLP-1 medications are prescription-only medications and are only prescribed to type-2 diabetics and those with obesity
Data from clinical studies were prioritized and, where relevant, specific preclinical studies were discussed
A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
A small effect on the bioavailability which was 12% lower when using the thigh compared with the abdomen but this was not clinically relevant
Diabetes Care 42 , 11471154 (2019)
