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Additionally, the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity trial demonstrated that semaglutide consistently reduced major cardiovascular event endpoints by approximately 20% compared to placebo over an approximately 3-year follow-up period in patients with overweight or obesity and cardiovascular disease (Table 1), but without diabetes [93]

Both medications help you feel full with less food by slowing gastric emptying and curbing appetite

It also slows down how quickly food leaves your stomach, further enhancing feelings of satiety

What happens when you stop each medication Weight regain after stopping weight loss medications is a reality for both classes, but the dynamics differ

Takeaway While GLP-1 agonists offer hope to millions suffering from obesity, it is important to point out that whatever a persons health goal, the basic tenet of achieving health is always to focus on diet, lifestyle, and attitude

The side effect profile of any GLP-1 patch would likely reflect both the systemic effects of GLP-1 receptor agonism (common to all delivery methods) and local effects specific to transdermal administration