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Funding This work was supported by the National Natural Science Foundation of China (81974254, 31870906, and 82170470)

Tirzepatide and CCR both corrected metabolic abnormalities of obese mice, reducing body weight and fat mass ( Supplementary Figure 2A-C ) and normalized the levels of metabolic hormones and glucose in circulation ( Table S1 ), with more substantial metabolic effects elicited by CCR than by tirzepatide

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