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During withdrawal, GLP-1 secretion by the NTS rises, increasing c-Fos and GLP-1 receptor expression in glutamatergic neurons of BLA, linked to heightened anxiety but not depression

As a segment, GLP-1 peptides are technically demanding and expensive to produce, making partnerships attractive for economies of scale and risk-sharing

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Combination Therapy: Semaglutide can be used as an adjunct to other antihypertensive medications to further enhance blood pressure control
