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However, a systematic review in 2023 found only one phase 2 randomized controlled trial of exenatide versus placebo for IIH, which did demonstrate a significant reduction in ICP at all time points, as well as improved headache and visual acuity (7,8)

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2022Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension

FIGURE 2: FDA-APPROVED GLP-1 RA MEDICATIONS Source: FDA-approved labeling for each medication (as of March 2025) You can calculate your BMI from height and weight using this online BMI calculator [archived link]

While liraglutide also showed cardiovascular benefit (13% reduction in the LEADER trial), semaglutides evidence is more recent, more robust, and specifically applicable to patients with obesity