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GLP-1 therapy may also be appropriate for those looking for a medically supervised alternative to short-term dieting

Patients taking metformin lose an average of 23 kg (47 lbs) over six months, while those on semaglutide lose 812 kg (1826 lbs) in the same timeframe

[DOI] [PubMed] [Google Scholar] 136.Tong C, Liang H, Liu X, Yuan B, Xue B, Tong Z, et al

These results enable us to recommend personalized daily calorie targets for optimal weight loss and energy levels

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By mid-2025, even that proved optimistic and on May 7, 2025, Novo cut its 2025 outlook and announced it expected only 814% sales growth and similarly reduced profit growth