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The first Phase 3 readout in February 2026 confirmed 28.7% weight loss with osteoarthritis pain relief

Key preparation steps include: If the pen has been refrigerated, allowing the Ozempic pen to reach room temperature (about 1520 minutes out of the refrigerator) before injection may reduce discomfort Cleaning the injection site with an alcohol wipe and allowing it to dry completely Inspecting the medication for particles or discolouration before each use Performing a flow check with a new pen as directed in the patient information leaflet Always using a new needle for each injection never reuse needles Never sharing your pen with anyone else, even if the needle is changed Patients should also consider their injection timing and environment

Conclusion Numbness and tingling can occur while you're taking Ozempic, but the medication is not clearly established as a common direct cause

This report by The Canadian Press was first published May 20, 2026

Tirzepatide is an FDA-approved prescription drug: Unlike most RUO peptides, tirzepatide has received full FDA approval as Mounjaro (type 2 diabetes, May 2022) and Zepbound (chronic weight management, November 2023)

Appetite suppression fades gradually, not overnightmeaning hunger returning can reflect reduced adherence to exercise, sleep loss, or increased stress eating