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This work was partially supported by National Natural Science Foundation of China 81872915 (MW), 82073904 (MW), 82121005 (DY), 81973373 (DY) and 21704064 (QZ)

Modulation of the enzyme proved challenging because it has multiple functions in the body

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Future research should prioritize elucidating the molecular mechanisms behind the antitumor effects, refining individualized treatment strategies, investigating early tumor prevention applications, assessing potential benefits for non-diabetic populations, advancing the development of novel therapies, establishing robust safety monitoring frameworks, and building precision medicine decision-making platforms

Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B