does glp 1 only work by suppressing appetite Why do GLP-1 medications so effectively when we already have suppressants? : r/GLP1ResearchTalk GLP-1 for Weight Loss and

Inhibition of NHE3 activity by GLP-1R agonism seems to be mediated via cAMP activation of PKA, which phosphorylates NHE3 at its Ser552 and Ser605 residues [660,771,772]

GLP-1s like Wegovy and Mounjaro have four mechanisms to improve blood sugar levels and support weight loss: Improve insulin function: Improving insulin response to glucose from meals enables the body to move glucose from the blood and into the cells (like muscle cells) to be burnt for energy or stored as glycogen

The anatomical distribution of GLP-1R throughout the reproductive system and several preclinical evidence support that GLP-1 can modulate the HPG axis activity at different levels, thus connecting reproductive functions, metabolic system, nutrition, and energy homeostasis mechanisms

However, it is crucial to understand that microdosing GLP-1 is not an evidence-based practice and lacks formal clinical trial data supporting its efficacy or safety

Exposed women were older with a higher mean BMI of 34 for women exposed to liraglutide compared to 23 for unexposed women, and a mean BMI of 33 for women exposed to semaglutide compared to 24 for unexposed women (equal to 47.837.5% higher BMI, for liraglutide and semaglutide exposure, respectively)

In animal studies, GLP1-agonists were associated with reduced fetal weight and/or growth, delayed ossification and skeletal variants, usually associated with a reduction in maternal weight gain and decreased food consumption