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These contradictory findings suggest that GLP-1 RAs effects on DBP may vary across studies [90, 91]

Biochem J 2017;474:182336

Comparison to tirzepatide (Mounjaro/Zepbound): Tirzepatide's SURMOUNT-1 trial (72 weeks) showed 22.5% weight loss at endpoint

Theres also interest in its anti-aging benefits, since boosting NAD+ and improving metabolism can have broad positive effects on health

Native GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), resulting in limited biological stability under experimental conditions

At the end of the study, there was no significant improvement in fertility or birth outcomes among the women who lost weight compared to those who didnt before TTC