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Discovery of multi-receptor agonists for the GIPR and GLP-1R The multifactorial nature of physiological control of metabolism and body weight, coupled with the demonstration that gastric bypass procedures increase secretion of GLP-1 and several other gut-derived hormones, suggested that engineering medicines combining GLP-1R activity with other hormonal stimuli might offer superior clinical outcomes

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

GLP-1 receptors in the hypothalamus, brainstem, and reward pathways modulate eating behavior at multiple levels

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