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Concerns remain about the quality of compounded GLP-1s

However, in vitro, evidence suggests that hyperglycemia, a primary metabolic feature of T2DM, can lead to impaired GLP-1 secretion and L-cell differentiation

Patients should disclose complete medical history, all medications, and family history of cancer or endocrine disease before starting GLP-1 treatment

This includes depressive disorders (F32-33), anxiety (F40-F48), and various aspects of suicidality

GLP-1 is a synthetic version of a hormone naturally released by your gut after you eat

For example, the SELECT trial revealed that patients on semaglutide maintained an average weight loss of -10.2% over four years (208 weeks), while the placebo group only saw a modest -1.5% reduction