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These results demonstrate that d-allulose improves glucose tolerance via potentiation of GLP-1R signaling

Insulin action in the human brain: evidence from neuroimaging studies

BMJ Open 9(5):e024065

Cloning and functional expression of a human glucagon-like peptide-1 receptor

Incretin analogues also show beneficial effects in heart failure, peripheral vascular disease, renal disease, obstructive sleep apnoea and metabolic dysfunction-associated steatohepatitis and have potential neuroprotective properties

Clinical manifestations of hypothyroidism secondary to Hashimoto's disease include: Fatigue and lethargy Weight gain despite normal appetite Cold intolerance Dry skin and hair loss Constipation Depression and cognitive impairment Bradycardia and elevated cholesterol Diagnosis is established through thyroid function tests showing elevated thyroid-stimulating hormone (TSH) with low free T4 (overt hypothyroidism) or normal free T4 (subclinical hypothyroidism), alongside positive thyroid antibodies