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Finally, the present study did not include long-term follow-up or clinical validation and thus the efficacy and safety of ASD combined with Semaglutide need to be confirmed in larger preclinical studies and clinical trials

Manufactured by Glenmark, it acts as a selective GLP-1 receptor agonist to deepen appetite control, stabilize glycemic profiles, and break through weight loss plateaus

Clinical data from 13 cardiovascular outcomes trials show semaglutide reduces major adverse cardiac events by 26% in people with type 2 diabetes or obesity

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27 Additional metabolic endpoints include markers of metabolic syndrome including body weight and waist and hip circumference

however, no clinical correlates have yet been shown in humans