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Each time a new gut peptide was identified, scientists tested its effect on insulin secretion, but only one intestinal hormone, GIP (glucose-dependent insulinotropic polypeptide), satisfied these criteria

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Furthermore, after 52 weeks of treatment, the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) improved significantly among participants in the tirzepatide arm compared with those in the placebo arm (between-group difference = 6.9 [95% CI 3.310.6]

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Thus, supporting the cardiovascular safety of these drugs and not necessarily their observed benefits