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Loomba R, Abdelmalek MF, Armstrong MF et al (2022) Semaglutide 2.4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial
WHAT IT DOES (mechanistically) Inhibits mitochondrial Complex I activates AMPK suppresses hepatic gluconeogenesis
In the trials, patients stopped the medication and the support around it, full stop
Thus, for many people, concerns about weight changes can overshadow efforts to quit and jeopardize chances of long-term success
1 These are two distinct evidence blocks at different doses
