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Additionally, the treatment of numerous comorbid chronic conditions presents issues of polypharmacy

Liraglutide and semaglutide have shown efficacy in reducing the -synuclein load in the chronic MPTP mouse model of PD [81]

Even with these adjustments, semaglutide combined with basal insulin led to HbA1c reductions of 1.4% to 1.8% over 30 weeks

The incidence of hypoglycemia was 0.6% in patients given placebo, 0.6% in patients given sitagliptin alone, 0.8% in patients given metformin alone, and 1.6% in patients given sitagliptin in combination with metformin

The agency didn't immediately respond to CNBC's request for comment