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Today, GLP-1 medications are among the most widely prescribed drugs in the United States

Unlike earlier GLP-1 receptor agonists, retatrutide is a triple agonist : GLP-1 receptor agonist suppresses appetite, slows gastric emptying, improves insulin sensitivity GIP receptor agonist enhances insulin release, amplifies GLP-1 effects Glucagon receptor agonist stimulates energy expenditure, fat metabolism, and potentially impacts lipid handling Clinical trials so far have shown remarkable weight loss (up to 24% in some studies) and strong metabolic improvements, including effects on lipids like LDL cholesterol

These results are clinically significant, as GLP-1RAs may offer an alternative approach for patients with PCOS

Oral contraceptives require absorption in the small intestine to reach effective blood levels

PMID: 24762441

Secondly, Trulicity slows down the emptying of the stomach, which helps to prolong feelings of fullness and increase satiety