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The metabolic improvements from weight losslike better insulin sensitivityoften persist even after the medication is paused, creating a foundation for maintaining a healthier weight during and after pregnancy

Ethical Approval Researchers accessed data in the format of a limited dataset for which data use agreements were in place with the covered entities in compliance with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule

Peer review Peer review information Nature Communications thanks Hironobu Hojo, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Better tolerance, fewer side effects, and improved adherence