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Potential protective effects may arise from multiple mechanisms, including the complex interplay between weight stigmatization, psychological distress, and improvements in overall health and self-perception among adolescents ( 15 , 16 )

Similarly, genetic differences in the FTO rs9939609 and MC4R rs17782313 genes affect metabolic rate and satiety signals, creating a biological foundation for treatment resistance

10.1016/j.bpobgyn.2010.10.016 [DOI] [PMC free article] [PubMed] [Google Scholar] Casteel C

Why We Picked Them: Many men manage testosterone and weight together, and few clinics serve that combination well

Semaglutide is a GLP-1 receptor agonist that slows gastric emptying, increases insulin secretion, and activates appetite-suppressing pathways in the brain