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Weight Gain : Many individuals who stop GLP-1 therapy experience weight regain, especially if they do not implement effective lifestyle changes

*Correspondence: Juan Pablo Del Ro, [email protected] This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Notable conformational differences were observed in the positions of peptide C-terminal half and the surrounding extracellular loop 1 (ECL1) and extracellular domain (ECD), indicative of GIPR-associated ligand specificity

Compounded tirzepatide follows similar patterns

Leveraging the GLP-1 receptor structure for drug discovery

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