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PMID: 40445127

1DF, half-maximal GEP44 binding at GLP-1R was observed at 113 nM ( versus 5.85 nM for Ex-4), 65.8 nM at Y2-R ( versus 1.51 nM for PYY 3-36 ), and 86.6 nM at Y1-R ( versus 7.9 nM for PYY 1-36 )

And its anabolic-related genes include fibroblast growth factor-21 (FGF21), SREBP-1c, fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC-a), liver X receptor (LXR), suppressor of cytokine signaling-3 (SOCS-3), etc

The experimental arm consisted of rats that consumed atherogenic diet, which promoted the evolution of NAFLD, as well as several other metabolic alterations (including dyslipidemia, systemic inflammation, increased oxidative stress and IR) [115]

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