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The specific amount of weight you might lose from Zepbound is uncertain, but significant weight loss ranging from 35.5 lb (16.1 kg) to 52.0 lb (23.6 kg) was observed in the 72-week SURMOUNT-1 clinical trial, which compared different Zepbound (tirzepatide) doses to a placebo (inactive treatment)

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Tirzepatide tends to cause slightly less nausea than semaglutide at equivalent efficacy levels, which is one reason some patients prefer it

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