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Zhang, J., et al

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GLP-1 based therapies: differential effects on fasting and postprandial glucose

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Besides affecting almost every tissue and organ, growth hormone promotes physical growth and normal metabolism.15 16 Its metabolic effects relate to its ability to stimulate the production of yet another hormone, insulin-like growth factor-1 (IGF-1)

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42 The mechanisms of these complex effects are still being elucidated, and it is unclear whether there is a direct effect via GLP-1 receptors in bone cells or indirect effects mediated through the gut

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In addition, hepatic 5-HTR 2A and 5-HTR 2B signaling might contribute to hepatic fibroblast growth factor-21 (FGF21) production and the pathophysiological mechanisms of type 2 diabetes (T2D) and metabolic dysfunction-associated fatty liver disease (MAFLD) [56]

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