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Diabetes Care 39:12411249 Kazierad DJ, Bergman A, Tan B et al (2016) Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus

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The substantial reduction in systemic inflammation, as indicated by high-sensitivity C-reactive protein (hs-CRP) levels, alongside improvements in overall metabolic health, such as weight loss and glycemic control, represents significant systemic alterations that may indirectly benefit the brain by mitigating chronic inflammatory stimuli and enhancing cerebrovascular health

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The cell bodies of vagal sensory neurons are clustered in the nodose ganglion, and recent transcriptomic profiling based on single-cell RNA sequencing analysis has identified more than a dozen genetically distinct subclasses [48, 49]

"More research is necessary to test the hypothesis