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In November 2023, a version of the drug was approved for chronic weight management in adults with obesity or who are overweight with at least one weight-related condition

doi: 10.1038/s41589-025-01888-2 23 ZhengJConradM
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However, with prolonged use, neuroendocrine adaptations and alterations in serotonergic regulation of appetite may lead to weight gain, as homeostatic mechanisms gradually adjust metabolic adaption over time
