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glp 1 gip glucagon Major physiological roles of GLP-1 and GIP. Tirzepatide is acting as an The Effects of Dual GLP-1/GIP
Description
The trial participants all took the drug for 36 weeks, at which point half continued with the drug, and half were switched to a placebo for another 52 weeks

New or worsening inflammatory bowel disease, including Crohns disease or ulcerative colitis, has been reported with medicines that affect IL-17 pathways

These are published, peer-reviewed findings from trials like SURPASS-CVOT, SURMOUNT-OSA, SYNERGY-NASH, and SUMMIT
[DOI] [PubMed] [Google Scholar] 34.Wilbon SS, Kolonin MG
Buse et al

These molecules facilitate leukocyte adhesion and trans endothelial migration, thereby accelerating plaque development
