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Fibrosis also improves with weight reduction, with 79.99 % or 10 % of weight reduction after 52 weeks of lifestyle intervention resulting in 50 % or 81 % of fibrosis regression, respectively, without any fibrosis worsening in adult patients with MASLD and baseline fibrosis on biopsy [39]

Originally studied for metabolic and glycemic control, semaglutide has since demonstrated significant efficacy in promoting sustained weight reduction by targeting the physiological drivers of appetite, caloric intake, and metabolic efficiency