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They found that people taking semaglutide (Ozempic) or tirzepatide versions of GLP-1 drugs were twice as likely to develop NAION (non-arteritic anterior ischemic optic neuropathy)

In preclinical in vitro work, GIPR signalling has been associated with lipid partitioning in adipocyte models and potentiation of insulin secretion under hyperglycaemic conditions
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In line with this, mice with an -cell specific knock-down of PC1/3, resulting in significantly reduced islet GLP-1 content, were able to maintain normal glucose tolerance, suggesting that islet GLP-1 may not be essential and/or that it can be compensated for by intestinally derived GLP-1 under normal conditions
The FDA stated it planned to restrict the use of GLP-1 ingredients, like semaglutide, in non-approved compounded drugs, which is what companies like Hims & Hers market as alternatives to the pricier, authorized treatments