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After initiation of SOLIQUA 100/33, observe patients carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

The most serious adverse effect is metformin-associated lactic acidosis a rare but potentially fatal build-up of lactic acid in the blood

[DOI] [PubMed] [Google Scholar] 38.Sidrak WR, Kalra S, Kalhan A

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These microbiome alterations are associated with greater intestinal barrier integrity, decreased endotoxemia, and increased synthesis of short-chain fatty acids