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The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure in a clinical trial, potentially expanding the already wildly popular drugs use beyond diabetes and weight loss and offering a new treatment option where few are available.

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After the 14 mg oral semaglutide dose failed to achieve significant weight loss, the 50 mg dose showed positive results in the OASIS-2 Trial

However, that is not the reality: even diabetic patients treated with GLP-1 RAs are more likely to stop them than other second-line anti-diabetic medicines.3 That study didnt report why 50% of diabetics on GLP-1 RAs discontinued them, but gastrointestinal (GI) adverse events were a suggested cause.3 Adverse events are just one of a number of reasons that people stop using these drugs, as follows.

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