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Yes, Mounjaro may cause chronic tiredness

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"A nausea medication or stool softener can mitigate these side effects but once you stop the GLP1 peptides, your appetite may come back in 3-4 weeks a healthy diet has to continue

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In studies where people stopped suddenly without further support, they regained about two-thirds of their lost weight within a year

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Ding L, Huwyler F, Long F, Yang W, Binz J, Wernle K, et al

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[Abstract]2025 Oct 30;243(Pt 1):117483

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