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The guide to whether tirzepatide makes you tired addresses the specific mechanisms

32,33 Under physiological conditions, besides the paracrine secretion pathway in the gastrointestinal tract, most endogenous GLP-1 in circulation is locally deactivated by DPP-4 and the liver, 34 making it difficult to directly enter the CNS through the blood-brain barrier

Diabetes Research And Clinical Practice, 172 ,

This creates a potential valuation disconnect compared with large-cap pharmaceutical incumbents and later-stage obesity therapy developers, particularly if the company successfully achieves meaningful clinical and regulatory milestones

If, for example, they fund more orals and multi-agonists, the medicine becomes more accessible to patient populations and it drives more demand for tech

approvals, so Canadians living with type 2 diabetes may be waiting a little longer