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Sometimes, this can lead to a sudden "crash" in blood sugar, resulting in irritability, dizziness, or intense fatigue later in the day

Groop PH, Dandona P, Phillip M et al (2020) Effect of dapagliflozin as an adjunct to insulin over 52 weeks in individuals with type 1 diabetes: post-hoc renal analysis of the DEPICT randomised controlled trials

Expected approval: 2027-2028 if Phase 3 data replicates Phase 2 results

Standard dosing follows a step-up schedule, increasing from 0.25 mg to 2.4 mg, as used in most trials

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However, detection and treatment of maternal subclinical hypothyroidism has also not been shown to cause improved pregnancy outcome and neurocognitive function in offspring [89,90]