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The medication works by enhancing insulin secretion in a glucose-dependent manner, suppressing inappropriate glucagon secretion, slowing gastric emptying, and reducing appetite

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However, we mitigated selection bias by consecutively including all eligible patients who underwent dose escalation from the time of semaglutide launch

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Use In Specific Populations Pregnancy Risk Summary Based on animal data showing adverse renal effects, XIGDUO XR is not recommended during the second and third trimesters of pregnancy