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Unprecedented in medical history is going to be a term used OFTEN in the next 6 months as these other trials report out

Severe nausea, vomiting, and diarrhea can lead to dehydration, which, in turn, may result in kidney dysfunction

Kidney Int 105(4S):S117S314 Perkovic V, Tuttle KR, Rossing P, FLOW Trial Committees and Investigators et al (2024) Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes

In this weight management program subjects treated with liraglutide 3.0 mg experienced a dose-dependent weight loss ranging from 6.0 kg to 8.8 kg, whereas subjects treated with placebo (on diet and exercise alone) had a mean weight loss of 0.2 kg to 3.0 k (209)

AUTHORS CONTRIBUTIONS All authors contributed equally to the conception, design, literature review, data interpretation, and drafting of the paper

They are part of a structured program built around eligibility screening, a prescription where appropriate, and ongoing supervision, and that structure is exactly what makes the approach a responsible one