glp-1 and dual glp-1/gip receptor agonists GIP/GLP-1 agonists: New advances for treating type-2 diabetes Targeting GLP-1, GIP & GCG

Another good way to determine the right dose is to check several pre-meal and 2-hour post-meal blood sugar levels, or to use a continuous glucose monitor (CGM) for breakfast and dinner over a few days

Understanding how GLP1R signalling protects the heart and blood vessels will optimize the therapeutic use and development of next-generation GLP1-based therapies with improved cardiovascular safety

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As illustrated in Figure 2, pooled analyses of cardiovascular outcome trials have demonstrated that GLP-1 RAs reduce major adverse cardiovascular events (MACEs) by 14% (HR = 0.86, 95% CI 0.790.94) in patients with type 2 diabetes, with additional significant benefits including 13% reduction in cardiovascular death, 16% reduction in nonfatal stroke, and 10% reduction in hospitalization for heart failure [85]

Gastaldelli A, Abdul Ghani M, DeFronzo RA

Comparing Mounjaro to Other GLP-1 Treatments When comparing Mounjaro to established GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) , dulaglutide (Trulicity) , and liraglutide (Victoza, Saxenda) , several key differences emerge