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doi: 10.1056/NEJMoa1607141 29 PratleyREArodaVRLingvayILdemannJAndreassenCNavarriaAet al

Improvement in lipid parameters was also demonstrated in the tirzepatide group, which may be due to the significant weight loss (Wadden et al

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Accordingly, moderate lean tissue decline observed during GLP-1RA-induced weight loss could be interpreted as a physiological component of body composition change rather than evidence of pathological sarcopenia, unless accompanied by functional deterioration

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