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While these studies suggest that GLP-1 influx into the brain might be a GLP-1R-independent process with passive diffusion of GLP-1 through the BBB [[750], [751], [752]], other studies suggest that uptake of liraglutide into the brain is GLP-1R-dependent [686,753]

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If the patient is unable to hold the GLP-1 receptor agonist for at least 3 half-lives before the procedure, consider rapid-sequence induction of general anesthesia, to reduce the risk of aspiration, and consider the use of point-of-care gastric ultrasonography, where available, to check for residual gastric content

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Genes encoding microfibril-associated and ECM-associated proteins are also generally downregulated in semaglutide-treated samples (except Dpt, Dcn, and F3, which are significantly upregulated)