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Nonspecific binding was determined in the presence of excess (15 M) unlabelled ghrelin or GLP-1

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These are the mechanistic questions most relevant to preclinical and translational researchers following the programme: Weight trajectory beyond 48 weeks, now partly answered Phase 2 was capped at 48 weeks, insufficient to observe the full weight nadir and plateau

Some report feeling a bit more fatigued during dose adjustments or while their body adapts

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