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6 Semaglutide mimics incretin hormones, enhancing insulin secretion, delaying gastric emptying, and suppressing appetite, leading to approximately 12% weight loss in clinical trials

Diabetes Metab Res Rev 26:287296

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The low placental transfer could be caused by the release of Dipeptidyl peptidase IV positive syncytiotrophoblast-derived extracellular vesicles released by the human placenta which degrade GLP-1 in uterine blood (63), as well as to the high molecular weight of GLP-1 agonists (4 73 kDa)

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Which is why they tasted awful