weight loss drugs glp-1 World Health Organization issues first-ever guidelines for use of medications GLP-1 Medications for Weight Loss:

Wang E, Zhu H, Wang X, et al

In subjects with BMI 30 kg/m 2 , but without T2D, a phase 1 single ascending dose (SAD) trial shows that GL0034 at doses of 1,520 mcg, 2,000 mcg, and 2,520 mcg results in mean weight loss of 2.1%, 1.9%, and 2.5%, respectively, versus 0.3% weight gain for the placebo group one week after administration (42)

While GLP-1 receptor agonists and Metformin are generally considered safe, each comes with specific rare side effects worth noting

10.2337/DC19-1465 [DOI] [PMC free article] [PubMed] [Google Scholar] Xiong Q.-F., Fan S.-H., Li X.-W., Niu Y., Wang J., Zhang X., et al

Roche/Genentech) Lupus nephritis (PDUFA: Oct 2025) November 4

42 (2), e1e12