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Also, because of its synergistic effect on two receptors, it has a greater effect on weight loss and blood sugar control than GLP-1s alone

423 Furthermore, the study emphasized that neurons in specific brain regions, such as the hindbrain and hypothalamus, co-express GLP-1R along with 1-adrenergic and -opioid receptors, suggesting a localized mechanism within the CNS that could coordinate peripheral anti-inflammatory responses

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60 YEARS OF POMC: From POMC and -MSH to PAM, molecular oxygen, copper, and vitamin C

Chen C, Zheng H, Xu J, Shi X, Li F, Wang X