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Semaglutide and other GLP-1-RAs are also shown to improve cardiovascular health and impart anti-inflammatory benefits in multiple organ systems

During the study body weight, water and food intake were weekly monitored, glycaemia biweekly and albuminuria and glomerular filtration rate (GFR) before and after the treatment

MOTS-c is a mitochondrial peptide that supports metabolic health by improving insulin sensitivity and energy production

Clinical trials show GLP-1 medications reduce heart attack and stroke risk in people with established cardiovascular disease, regardless of baseline weight

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Finally, since endogenous GLP-1 is involved in the regulation of energy metabolism both in the periphery as well as in the brain, compounds acting as GLP-1R agonists can also normalize mitochondrial function, which also appears to be repeatedly disrupted in the depressive brain and thus possibly exacerbate neuroprotective effects, e.g