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Materials and methods The overall metabolism of GLP-1 and exendin-4 was directly compared in anaesthetised pigs (n=9)

Researchers performed a phase III randomized clinical trial (RCT).

In November 2025, the Trump administration announced landmark agreements with Eli Lilly and Novo Nordisk reducing the monthly price of GLP-1 weight-loss drugs from over $1,000 to as low as $245 for eligible patients

The development of multi-agonists with multi-organ targets may alter the natural history of these diseases

Though lifestyle modification remains the main pillar of management, with advances in the treatment of obesity, newer agents are being tried for patients with MAFLD

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