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After adjustment for sex, BMI, hsCRP, and sCD163, semaglutide significantly decreased epigenetic aging: PCGrimAge (-3.1 years, P = 0.007), GrimAge V1 (-1.4 years, P = 0.02), GrimAge V2 (-2.3 years, P = 0.009), PhenoAge (-4.9 years, P = 0.004), and DunedinPACE (-0.09 units, 9 % slower pace, P = 0.01)

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These figures highlight how, even with broader coverage, patient behavior and systemic barriers continue to erode both demand and health outcomes in this rapidly evolving market

in combination with insulin, when diet and exercise regimen in combination with insulin do not lead to adequate glycemic control.

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